Fig 1: Comparison of diagnostic accuracies for liver fibrosis stage.The receiver operating characteristic curves of serum SAP, serum PPBP, type IV collagen 7S, hyaluronic acid, and the FIB-4 index for diagnosing patients with F=2, those with F=3 and those with F4 are shown. Abbreviations: SAP, serum amyloid P component; PPBP, pro-platelet basic protein; FIB-4 index, fibrosis-4 index.
Fig 2: The relative quantitative values of 3 SAP-targeted peptides and 1 PPBP-targeted peptide.The dot plot shows individual values. The data are expressed as the mean ± standard deviation. Abbreviations: SAP, serum amyloid P component; PPBP, pro-platelet basic protein.
Fig 3: The results of serum SAP and PPBP measurements in patients with chronic hepatitis C.(A) The correlations between serum SAP or PPBP and their corresponding peptides evaluated by the Pearson product-moment correlation coefficient. (B) Serum SAP and PPBP levels in patients with chronic hepatitis C from the validation cohort. Levels in patients with colorectal polyps without liver disease are shown as controls. The dot plot shows individual values. The data are expressed as the mean ± standard deviation. The p-values calculated by the Jonckheere-Terpstra test for the trend in patients with chronic hepatitis C are shown. (C) The correlations of serum SAP or PPBP levels with type IV collagen 7S and hyaluronic acid levels evaluated by calculating the Pearson product-moment correlation coefficient. (D) The correlations between serum SAP and PPBP levels evaluated by calculating the Pearson product-moment correlation coefficient. Abbreviations: SAP, serum amyloid P component; PPBP, pro-platelet basic protein.
Fig 4: The results of shotgun proteomic analysis.(A) Heatmap of 445 EV proteins that were detected in more than half of the patients. (B) Relative quantitative value of IGHV, GAPDH, C1s, GRP78, V-ATPase, PPBP, CD9, Lp(a) and SAP. The dot plot shows individual values. The data are expressed as the mean ± standard deviation. Abbreviations: IGHV, Ig heavy chain V-II region WAH; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; C1s, complement C1s subcomponent; GRP78, 78 kDa glucose-regulated protein; V-ATPase, ATPase H+ transporting V0 subunit a1; PPBP, pro-platelet basic protein; CD9, CD9 antigen; Lp (a), lipoprotein (a); SAP, serum amyloid P component.
Supplier Page from Abcam for Human CXCL7 / PBP ELISA Kit